Stepwise synaptic plasticity events drive the early phase of memory consolidation


Yasunori Hayashi


  1. Systems consolidation
  1. Synaptic plasticity.
    • Early phase of sLTP –> rapid polymerization of actin –>enlarge their structure.
    • Low cofilin(CFL) –> F-actin disassembly
    • High cofilin –> cofilaction –> stabilizing F-actin

In the CA1 region of the hippocampus, LTP is initiated by the entry of Ca2+ through NMDA-type glutamate receptors (NMDARs), which triggers the translocation of specific proteins to the synapse, including AMPA-type glutamate receptors (AMPARs; Hayashi et al., 2000). This early phase of LTP (E-LTP) requires the rapid polymerization of actin and the activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Okamoto et al., 2009).To further consolidate E-LTP into the late phase (L-LTP), the synthesis and transport of new proteins into potentiated synapses are required (Kelleher et al., 2004).


  1. 光遗传消除sLTP

MNI-glutamate (12 mM) was then applied locally from a glass pipette positioned close to the selected dendrite. Repetitive (1 or 2 Hz) photolysis of MNI-glutamate was performed on the specimen at a 720-nm wavelength with a pulse-train duration of 0.6 ms and a power of ∼5 mW.

—-Matsuzaki, Masanori, et al. “Structural basis of long-term potentiation in single dendritic spines.” Nature 429.6993 (2004): 761-766..

As the filaments treadmilled, nonactivated PAGFP-actin took the place of activated PAGFP-actin. Eventually, the activated PAGFP-actin reached the end of the filament, depolymerized, and diffused away.

—-Honkura, Naoki, et al. “The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.” Neuron 57.5 (2008): 719-729.
  1. Time window of optical erasure of sLTP
  1. 在一定时间窗口内光遗传消退LTP损坏情景特定记忆
  1. 在睡眠期间消退LTP也会影响记忆
  1. 在后一天ACC消退睡眠阶段LTP影响记忆


Goto, Akihiro, et al. “Stepwise synaptic plasticity events drive the early phase of memory consolidation.” Science 374.6569 (2021): 857-863.


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